Possible Interaction: Edetic Acid and Cobaltous Cation

“Both enzymes were significantly activated with Co2+ and inhibited with EDTA.”

“Chelation of Ni(II) and Co(II ) ions with EDTA almost completely inhibited product formation.”

“ EDTA treatment resulted in a marked decline in both activities, and restoration of FAD pyrophosphatase activity but not 5'-nucleotidase activity was accomplished by the addition of Co2+ or, to a lesser extent, Mn2+.”

“ EDTA caused a marked suppression, which could be prevented by Co2+ and Zn2+.”

“ EDTA caused a strong suppression, which could be prevented by Co2+ and Zn2+.”

“Its activity was not inhibited by DTT and EDTA , but strongly inhibited by Cu2+, Zn2+, and Co2+.”

“It is activated by Co2+ and inhibited by beta-mercaptoethanol and EDTA.”

“The effect of EDTA is partially reversed by Co2+ or Zn2+ ions.”

“ EDTA was able to counteract the … effect of Cu(II) or Co(II ) on kynurenine aminotransferase and partially counteract the inhibitory effect of Cu(II), Co(II) on kynurenine aminotransferase and … counteract the inhibitory effect of Cu(II), Co(II), Pb(II) or Zn(II) ions on kynurenine hydrolase.”

“Addition of Zn2+ and Co2+ (final concentration 10−3 M of each) in the presence of EDTA not only recovers the lost activity but also activates the enzyme considerably.”

“Enzyme activity slightly increased with Co2+ but was strongly inhibited by EDTA.”