Possible Interaction: Edetic Acid and Calcium Supplement

“Due to … ability of EDTA to … Ca [11], the process might have effects on PS translocation from the inner to the outer leaflet of the cell membrane, which … result in less PS binding to Annexin V. The Annexin V-positive cell number might be reduced in flow cytometry analysis.”

“Chelation of calcium ions by EDTA or warfarin treatment of cells led to loss of ability of MGP to bind BMP-4.”

“After exposure to EDTA , the calcium ion concentration in semen was reduced as a function of EDTA concentration, which yielded a linear reduction of sperm motility.”

“Calcium ion was shown to play an essential role in regulating sperm molitility in semen, and EDTA was demonstrated to exert spermicidal activity by modulating calcium ion concentration in semen.”

“All were inhibited by 10 mM EDTA , and reactivated by 10 mM calcium.”

“ Calcium directly inhibited responsiveness of hCG-sensitive AC; inhibition was significant at 0.5 mM CaCl2 (in the presence of 1 mM EDTA and 2 mM ATP), being 90% at 2.5 mM CaCl2.”

“This aggregation was inhibited by EDTA and could be reversed by Ca 2+ .”

“Thus, the inhibition by EDTA is due to binding to calcium associated with factor V. In 8 M urea, EDTA can remove over 80% of the calcium , demonstrating the importance of the native structure in maintaining the calcium binding site.”

“Divalent cations such as Ca++ and Mg++ activated the myosin ATPase activity, whereas EDTA inhibited the enzyme activity.”

“Administered shortly after EDTA, Ca++ , Mg++, Sr++, but not Fe++, Fe+++, or Zn++ counteracted the inhibition by EDTA.”

“CONCLUSIONS Irrigation activation techniques with ED A or CA in creased the release levels of all growth factors from the dentine of extracted teeth.”