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“From experiments with aspirin-treated human platelets we now present evidence that ebselen also affects intracellular calcium homeostasis by inhibiting the agonist-triggered increase in intracellular calcium.”
“In contrast, when the cells were treated with Se in the form of ebselen , a thiol oxidant with peroxidase-like activity, histamine-induced calcium release and calcium entry were significantly suppressed.”
European journal of pharmacology • 2010 | View Paper
“The mechanism by which diphenyl ditelluride and ebselen interact with Ca2+ channel is unknown, but may be related to reactivity with critical sulfhydryl groups in the protein complex.”