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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Droperidol and Gamma-Aminobutyric Acid

Research Papers that Mention the Interaction

Conclusions Droperidol inhibits activation of both the GABAA &agr;1&bgr;1&ggr;2 and &agr;7 nAChR. The submaximal GABA inhibition occurs within a concentration range such that it might be responsible for the anxiety, dysphoria, and restlessness that limit the clinical utility of high-dose droperidol anesthesia.
Results Droperidol inhibited the GABA response by a maximum of 24.7 ± 3.0%.
Anesthesiology  •  2002  |  View Paper