“Conclusions Droperidol inhibits activation of both the GABAA &agr;1&bgr;1&ggr;2 and &agr;7 nAChR. The submaximal GABA inhibition occurs within a concentration range such that it might be responsible for the anxiety, dysphoria, and restlessness that limit the clinical utility of high-dose droperidol anesthesia.”
“Results Droperidol inhibited the GABA response by a maximum of 24.7 ± 3.0%.”