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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Droperidol
supplement:
Epinephrine
Research Papers that Mention the Interaction
“In both species, additional doses of droperidol were effective against CFRs augmented with intravenous epinephrine , a catecholamine that stimulates thrombosis.”
High‐dose Droperidol Protects against Experimental Coronary Thrombosis in Dogs and Pigs and Attenuates Aggregation of Porcine Platelets and Ca2+ Mobilization in Human Platelets“The increase in plasma epinephrine levels was likewise inhibited by droperidol ; significantly lower plasma norepinephrine levels also were observed.”
“Injection into the oxygenator during cardiopulmonary bypass caused a transient reduction in arterial pressure, and when the effect of droperidol was maximal, peripheral vasoconstriction produced by adrenaline and noradrenaline was completely suppressed or severely attenuated for a period sometimes exceeding 10 minutes.”
“The results showed that at clinically relevant concentrations, droperidol significantly slows ventricular pacemaker activity, a depression reversible by epinephrine.”
Effects of droperidol on depolarization-induced automaticity, maximum upstroke velocity (Vmax) and the kinetics of recovery of Vmax in guinea-pig ventricular myocardium.“Dexclamol, however, was approximately 37 times less potent than droperidol in antagonizing the vasopressor effects of epinephrine.”
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