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“The efficacy of the delayed-release combination of doxylamine and pyridoxine (Bendectin, Diclectin) has been shown in several randomized, controlled trials.”
The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique • 2000 | View Paper
“The combination of doxylamine and pyridoxine , for example, has been associated with limb reduction defects in isolated case reports: cohort and case-control studies have failed to show a higher-than-baseline risk of malformations.”