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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Doxycycline
supplement:
Ferrous Sulfate
Research Papers that Mention the Interaction
“SummaryIn a double-blind cross-over study in seven patients, oral ferrous sulphate (80 mg Fe++) given 3, 7 and 11 h after a daily oral dose of doxycycline , lowered the serum concentration of doxycycline by 20–45%.”
Effect of oral ferrous sulphate on the half-life of doxycycline in man“ Ferrous sulphate administered together with tetracycline and three of its derivatives—oxytetracycline, methacycline, and doxycycline —was found seriously to impair the absorption of these antibiotics.”
“The serum half-life and AUC of DC were reduced by ferrous sulphate given after the 100 mg+100 mg dose of DC.”
“… oral ferrous sulphate can lower the serum … half-life of DC , the acute experiment suggested that a therapeutic serum level of DC can be maintained despite treatment with iron in … iron-deficiency, and charcoal in the doses used in diarrhoeic states, if the drugs are administered several hours apart.”
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