Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Doxycycline and Ferrous Sulfate

Research Papers that Mention the Interaction

SummaryIn a double-blind cross-over study in seven patients, oral ferrous sulphate (80 mg Fe++) given 3, 7 and 11 h after a daily oral dose of doxycycline , lowered the serum concentration of doxycycline by 20–45%.
European Journal of Clinical Pharmacology  •  2004  |  View Paper
Ferrous sulphate administered together with tetracycline and three of its derivatives—oxytetracycline, methacycline, and doxycycline —was found seriously to impair the absorption of these antibiotics.
British medical journal  •  1970  |  View Paper
The serum half-life and AUC of DC were reduced by ferrous sulphate given after the 100 mg+100 mg dose of DC.
oral ferrous sulphate can lower the serum … half-life of DC , the acute experiment suggested that a therapeutic serum level of DC can be maintained despite treatment with iron in … iron-deficiency, and charcoal in the doses used in diarrhoeic states, if the drugs are administered several hours apart.
European Journal of Clinical Pharmacology  •  2004  |  View Paper