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Discover Supplement-Drug Interactions

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Last Updated: 4 months ago

Possible Interaction: Doxycycline and Calcium Supplement

Research Papers that Mention the Interaction

Doxycycline not only inhibits active MMPs by chelating zinc at the catalytic site but also reduces levels of total collagenase and total gelatinase in osteoarthritic cartilage, apparently by affecting enzyme stability through the chelation of intramolecular calcium [6].
Annals of Internal Medicine  •  1997  |  View Paper
The results showed that doxycycline significantly decreased the deposition of calcium , reduced the relative calcification area and alleviated pathological injury in aortic tissues.
Microvascular research  •  2017  |  View Paper
Treatment with doxycycline decreased aortic calcium and phosphorus accumulation, and it reduced aortic gelatinase levels; however, it also prevented the bone resorption associated with high doses of vitamin D3.
Arteriosclerosis, thrombosis, and vascular biology  •  2006  |  View Paper