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Discover Supplement-Drug Interactions
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Last Updated: 4 months ago
drug:
Doxycycline
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“ Doxycycline not only inhibits active MMPs by chelating zinc at the catalytic site but also reduces levels of total collagenase and total gelatinase in osteoarthritic cartilage, apparently by affecting enzyme stability through the chelation of intramolecular calcium [6].”
Putting Some Muscle into Osteoarthritis“The results showed that doxycycline significantly decreased the deposition of calcium , reduced the relative calcification area and alleviated pathological injury in aortic tissues.”
Doxycycline affects gene expression profiles in aortic tissues in a rat model of vascular calcification.“Treatment with doxycycline decreased aortic calcium and phosphorus accumulation, and it reduced aortic gelatinase levels; however, it also prevented the bone resorption associated with high doses of vitamin D3.”
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