Possible Interaction: Doxorubicin Hydrochloride and Tocophersolan

“Meanwhile, the photothermal heat can also boost the release of doxorubicin hydrochloride whose intracellular accumulation can be greatly enhanced by TPGS.”

“Meanwhile, the TPGS component synergistically improved the cytotoxicity of DOX by targeting mitochondrial organelles and reducing the mitochondrial transmembrane potential.”

“It was found that the cellular uptake of DOX increased 15.2% by TPGS conjugation and further 6.3% by FOL conjugation after 0.5-h cell culture.”

“The PEG attachment decelerated the release of both the doxorubicin and the sorafenib, however, the release of the latter drug remained still significantly faster with increased initial burst compared to doxorubicin.”

“In MCF- 7/Dox cells, the drug resistance seems to be decreased when Dox is loaded onto TPGS containing NPs.”

“The insertion of TPGS decreased the P-glycoprotein activity, increased the intracellular accumulation doxorubicin , and also increased the therapeutic efficacy of the resulting nanoparticles.”

“This combination of photodynamic activity in a powerful nanocarrier loaded with the chemotherapeutic agent doxorubicin can be used to deliver two types of cancer therapy simultaneously, and the addition of TPGS can further enhance the entry of doxorubicin into the nucleus.”

“Co-administration of TPGS enhanced the cytotoxicity of doxorubicin , vinblastine, paclitaxel, and colchicine in the G185 cells to levels comparable to the parental cells.”

“In drug-resistant cells, TPGS effectively prolonged intracellular Dox retention time and siRNA-corona did improve the internalization of Dox from liposomes.”