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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Polypeptides
Research Papers that Mention the Interaction
“Haemolysis assays demonstrated that the polypeptide was haemocompatible, and the polypeptide drug carrier significantly reduced the haemolysis ratio of DOX·HCl.”
Doxorubicin-loaded polypeptide nanorods based on electrostatic interactions for cancer therapy.“In vitro cytotoxicity and hemolysis assays demonstrated that the block copolypeptide was cytocompatible and hemocompatible, and the presence of copolypeptide carrier could reduce the hemolysis ratio of DOX·HCl significantly.”
“The spontaneous formation of polymersomes with uniform size is found to occur in aqueous medium via electrostatic interaction between the anionic polypeptide and cationic doxorubicin hydrochloride (DOX·HCl).”
“ Doxorubicin intercalates into mitochondrial DNA (mtDNA) and disrupts genes encoding for polypeptides that make adenosine triphosphate.”
“Inhibition of c-Myc and Max dimerization by this polypeptide leads to as much as a 2-fold reduction in the doxorubicin and etoposide IC(50) in three different cell lines tested.”
“This report demonstrates that pretreatment of cells with a polypeptide , which inhibits c-Myc transcriptional function causes cells to be more susceptible to the topoisomerase II inhibitors doxorubicin and etoposide.”
“Two co-regulated polypeptides around 64 kDa (termed p64) were induced 10-30-fold in response to adriamycin and some other drugs at the IC50 (the concentration inhibiting cell growth by 50%).”
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