Possible Interaction: Doxorubicin Hydrochloride and Green Tea Extract

“Nonetheless, simultaneous administration of doxorubicin and antioxidants, such as those found in green tea leaves , could reduce cardiac and renal tissue damage caused by oxidative stress.”

“Moreover, GTE administration significantly increased the activities of glutathione peroxidase (GPX), glutathione reductase (GR), glutathione s-transferase (GST), superoxide dismutase (SOD) and catalase (CAT), in heart, which were reduced by DOX treatment.”

“The determination of total lipid fatty acid composition, of conjugated diene production (indicator of lipid peroxidation), and of lactate dehydrogenase release revealed that supplementation with tea extracts could counteract significant modifications in the fatty acyl pattern due to doxorubicin exposure, although to different extents.”

“A combined treatment with GTE and DOX showed a considerable decrease in serum markers of cardiotoxicity such as LDH, CK, SGOT and lipid peroxides.”

“Thus it can be concluded that GTE possesses an antioxidant activity and by virtue of this action it can protect the heart from DOX induced cardiovascular abnormalities.”