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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Doxorubicin Hydrochloride and Glabridin

Research Papers that Mention the Interaction

First, we found that GBD could decrease the half maximal inhibitory concentration of paclitaxel and doxorubicin (DOX) in breast cancer cells like MDA‐MB‐231/MDR1 cells and MCF‐7/ADR cells.
In …, GBD can increase the accumulation of DOX in MDA‐MB‐231/MDR1 cells by suppressing the expression of P‐gp and competitively inhibiting the P‐gp efflux pump and enhance the apoptosis of MDA‐MB‐231/MDR1 cells induced by DOX, and thus realize reversal effects on MDR.
It was further explained that GBD enhanced the apoptosis of MDA‐MB‐231/MDR1 cells induced by DOX , due to the increased accumulation of DOX.
On the other hand, GBD can downregulate the activity of P‐gp ATPase when cotreated with DOX or verapamil, revealing that GBD was a substrate of P‐gp.
European journal of pharmacology  •  2019  |  View Paper
Glab also potentiated the cytotoxic effect of DOX and its accumulation in H1299 cell line.
Advanced pharmaceutical bulletin  •  2019  |  View Paper