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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glabridin
Research Papers that Mention the Interaction
“First, we found that GBD could decrease the half maximal inhibitory concentration of paclitaxel and doxorubicin (DOX) in breast cancer cells like MDA‐MB‐231/MDR1 cells and MCF‐7/ADR cells.”
“In …, GBD can increase the accumulation of DOX in MDA‐MB‐231/MDR1 cells by suppressing the expression of P‐gp and competitively inhibiting the P‐gp efflux pump and enhance the apoptosis of MDA‐MB‐231/MDR1 cells induced by DOX, and thus realize reversal effects on MDR.”
“It was further explained that GBD enhanced the apoptosis of MDA‐MB‐231/MDR1 cells induced by DOX , due to the increased accumulation of DOX.”
“On the other hand, GBD can downregulate the activity of P‐gp ATPase when cotreated with DOX or verapamil, revealing that GBD was a substrate of P‐gp.”
Glabridin resensitizes p‐glycoprotein‐overexpressing multidrug‐resistant cancer cells to conventional chemotherapeutic agents“ Glab also potentiated the cytotoxic effect of DOX and its accumulation in H1299 cell line.”
Evaluation of the Cytotoxic and Apoptogenic Effects of Glabridin and Its Effect on Cytotoxicity and Apoptosis Induced by Doxorubicin Toward Cancerous Cells
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