Possible Interaction: Doxorubicin Hydrochloride and Garlic

“ AGE has been shown to protect against the cardiotoxic effects of doxorubicin , an antineoplastic agent used in cancer therapy and against liver toxicity caused by carbon tetrachloride (an industrial chemical) and acetaminophen, an analgesic.”

“ AGE can effectively and extensively counteract this action of DOX and may potentially protect the heart from severe toxicity of DOX.”

“ AGE pretreatment did not interfere with the cytotoxic activity of DOX, but it increased the DOX uptake into tumor cells and increased the long term survivors of tumor-bearing mice from 30% to 70%.”

“DOX increased p53 and caspase 3 activity–induced apoptotic cell death, whereas AGE pretreatment suppressed the action of DOX.”

“Moreover, the study investigated if the cardioprotective effect of AGE might be at the expense of the antitumor effect of the anticancer drug doxorubicin (DOX).”

“However, pretreatment of rats with aged garlic extract (250 mg/kg) for 27 days before doxorubicin therapy , reduced the activity of both enzymes, and significantly decreased of MDA production in plasma.”

“Our results suggest that aged garlic extract is potentially protective against doxorubicin-induced cardiotoxicity.”

“Increase in myocardial TBARS and decrease in endogenous antioxidants by adriamycin was prevented significantly in the garlic treated rat hearts, which was comparable to the probucol-treated group.”

“Probucol, 250 mg/kg and 500 mg/kg of garlic reduced adriamycin induced TNF-α expression in the myocardium and was associated with reduced myocyte injury.”

“Thus, on administration of adriamycin to mice fed diets containing 20 mg/kg or 100 mg/kg garlic , the drug‐induced increase in MDA generation was 38.2% and 22.5% respectively, less than that produced by adriamycin in mice fed normal diets, containing no garlic (105.4%).”

“… garlic had no significant effects on the basal levels of the antioxidant enzymes or MDA generation in red blood cells … with adriamycin), at doses of 20 mg/kg or 100 mg/kg, garlic was able to decrease significantly the adriamycin induced changes in the oxido‐… the red blood cells.”

“Combination of AGE attenuated the cardiotoxic effects-induced by ADR through its antioxidant and cytoprotective potentials.”

“However, combination of AGE attenuated most of the histopathological, ultrastructural, and biochemical changes induced by ADR.”

“Therefore, AGE can use as adjunct during administration of ADR in cancer therapy.”