“After 24 h, doxorubicin upregulated p53 mRNA expression, disturbed Bcl-2 family protein balance, disrupted mitochondrial membrane potential, precipitated mitochondrion-dependent apoptotic signalling, induced apoptotic cell death, and reduced viability of cardiomyocytes, whereas EGb761 pretreatment suppressed all the actions of doxorubicin.”
“ EGb761 can effectively and extensively counteract this action of doxorubicin , and may potentially protect the heart from the severe toxicity of doxorubicin.”