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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Doxorubicin Hydrochloride and Egb 761

Research Papers that Mention the Interaction

Thus, EGb761 may find use as promising adjuvant therapy to ameliorate cardiotoxicity of ADR.
Indian journal of biochemistry & biophysics  •  2013  |  View Paper
After 24 h, doxorubicin upregulated p53 mRNA expression, disturbed Bcl-2 family protein balance, disrupted mitochondrial membrane potential, precipitated mitochondrion-dependent apoptotic signalling, induced apoptotic cell death, and reduced viability of cardiomyocytes, whereas EGb761 pretreatment suppressed all the actions of doxorubicin.
EGb761 can effectively and extensively counteract this action of doxorubicin , and may potentially protect the heart from the severe toxicity of doxorubicin.
Cardiovascular research  •  2008  |  View Paper
Therefore, EGb confers a beneficial chemopreventive effect against BP-induced gastric carcinogenesis in mice, and possesses a salutary ameliorating potential on the cardiotoxic effects of Dox.
Journal of experimental & clinical cancer research : CR  •  2001  |  View Paper