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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“These data show that intravesical CA instillation in combination with MMC or ADM is more effective for the prevention of recurrence than that of CA alone.”
[Intravesical instillation chemotherapy of anticancer agents including cylocide: studies of prophylactic effects on the recurrence].“RESULTS We observed that do orubicin tr eatment increased intracellular cal cium an d ROS (Reactive Oxygen Species) in parental and doxorubicin resistant T47D cells.”
“In cells of donor B cytoplasmic and intranuclear calcium concentration decreased if Doxorubicin concentration ≥ 0.2 µg/ml.”
“Consistent with these observations in fission yeast, calcium also suppressed doxorubicin cytotoxicity in human breast cancer cells.”
“Further epistasis analyses in yeast showed that this suppression of doxorubicin toxicity by calcium was synergistically dependent on Rav1 and Vph2, two regulators of vacuolar‐ATPase assembly; this suggests potential modulation of the calcium–doxorubicin interaction by fluctuating proton concentrations within the cellular environment.”
“Unexpectedly, we observed a suppressive effect of calcium on doxorubicin cytotoxicity, where concurrent calcium and doxorubicin treatment resulted in significantly higher cell survival compared with cells treated with doxorubicin alone.”
“The present data suggest the potency of the calcium ion as an enhancer of ADM.”
“Furthermore, our results showed that cotreatment with EBB and doxorubicin resulted in marked G(2)/M arrest and apoptosis of MCF-7/ADR cells, accompanied by down-regulation of the proteins cdc2/p34 and cyclin B1 and increased the levels of calcium ions.”
“Calcein viability assays showed that doxorubicin (0.5 microM for 24 h) decreased cell viability by ca.”
“The release of [32P] inositol 1,4-bisphosphate and [32P] inositol 1,4,5-trisphosphate and the breakdown of the inositol lipids in response to calcium (2.5 x 10(-4) and 10(-3) mol/l) stimulation was enhanced by doxorubicin (10(-6) to 10(-12) mol/l).”
“ Adriamycin , paradoxically, appeared to cause a fall in the levels of erythrocyte polyphosphoinositides, but prevented further breakdown induced by calcium loading.”
“Furthermore Dox altered intracellular mediators as catalytic free iron (-75%), H₂O₂(-75%) and calcium (+30%).”
Efficacy of grape seed and skin extract against doxorubicin-induced oxidative stress in rat liver.
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