Possible Interaction: Doxorubicin Hydrochloride and Apigenin

“Our finding provides evidence that apigenin sensitizes BEL-7402/ADM cells to doxorubicin through miR-520b/ATG7 pathway, which furtherly supports apigenin as a potential chemo-sensitizer for hepatocellular carcinoma.”

“We observed that apigenin significantly enhanced doxorubicin sensitivity, induced miR-520b expression and inhibited ATG7-dependent autophagy in BEL-7402/ADM cells.”

“Moreover, apigenin inhibited not only P-glycoprotein but also BCRP by increasing cellular uptake of doxorubicin and synergistic inhibition of cell viability in combination with doxorubicin or docetaxel in multidrug-resistant cells.”

“In conclusion, both apigenin and hesperidin enhance the cytotoxic effects of doxorubicin on breast cancer cells, and this phenomenon occurs regardless of oxidative stress but is accompanied by disorders of DNA damage response mechanisms.”

“ Apigenin also exhibited synergistic activity in combination with doxorubicin toward HEK293-STAT1 cells.”

“WWGPE, apigenin , and ferulic acid exhibited concentration dependent cyto-protective effect against Dox (1 μM) in rat cardiomyocytes.”

“ Apigenin decreased doxorubicin-induced , but not cyclophosphamide-induced mutagenicity in vitro.”

“RESULTS Ap genin an d dox orubicin do se-dependently inhibited cell survival, and co-administration of both agents significantly induced cell death via upregulating the mRNA expression of caspases, Bax and cytochrome c, and downregulating Bcl-XL.”

“The combination of apigenin and doxorubicin inhibited PI3K and AKT phosphorylation more strongly than a single administration.”

“However, in the myeloid cell lines the effects of the combination treatments varied; doxorubicin had a synergistic or additive effect when combined with quercetin, apigenin , emodin, and cis-stilbene, but had an antagonistic effect when combined with rhein.”