Possible Interaction: Dopamine and Vitamin D

“RESULTS Serum levels of 25(OH)D and do amine si gnificantly increased in the vit amin D gr oup, compared to the placebo group (p < 0.05).”

“ Vitamin D affects dopamine synthesis and metabolism as well as expression of glial cell line–derived neurotrophic factor (GDNF), which is crucial for the survival of dopaminergic neurons.”

“ Vitamin D may exert protective and neurotropic effects directly at cellular level, e.g. protection of dopamine system , and/or by regulating gene expression.”

“In the absence of guanylnucleotide, dopamine had a 24-fold higher apparent affinity at D3 than at D2 receptors.”

“It has been reported that vitamin D affects the nigrostriatal dopaminergic pathway, increases the levels of dopamine or its metabolites and protects dopaminergic neurons against toxins [2].”

“ Vitamin D appears to be involved in neurophysiology in regulating, at the level of gene transcription, the synthesis of multiple neurotransmitters, including acetylcholine and dopamine.”

“ Vitamin D is known to increase levels of dopamine and its metabolites in the brain and also protects dopaminergic neurons against dopaminergic toxins.”

“ CC not only upregulates the cerebral pro-inflammatory cytokines including tumor necrosis factor α (TNF-α) and interleukin 8 (IL-8), but also downregulates the cerebral interleukin 10 (IL-10), an anti-inflammatory cytokine, and tyrosine hydroxylase (TH), a ratelimiting enzyme for biosynthesis of the anti-inflammatory neurotransmitter dopamine.”