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Last Updated: 4 months ago

Possible Interaction: Dopamine and Vitamin B 6

supplement:

Vitamin B 6

Research Papers that Mention the Interaction

Pyridoxine … DA generation from exogenous DOPA and attenuated the DOPA-induced increases in plasma and urinary DOPA and its metabolite 3-O-methyl-DOPA, but accentuated … in free DA and its main metabolites, dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), while BP, ANF, cGMP, PRA, and PA remained unaffected.
American journal of hypertension  •  1993  |  View Paper
The blocking of the systemic uptake of dopamine has eliminated the previous complications of nausea, vomiting, and cardiac and respiratory arrhythmias; pyridoxine need not now be avoided.
Annals of internal medicine  •  1981  |  View Paper
Meth-pretreated adolescent B6 and DBA mice exhibited losses in striatal DA concentrations; DBA adolescents also showed losses in striatal 3,4-dihydroxyphenylacetic acid (DOPAC) and increased DA turnover.
Neurotoxicology  •  2011  |  View Paper
Administration of each component at doses equimolar to 1 mg metadoxine showed that pyridoxine produced only a mild increase in striatal dopamine compared with controls.
The Journal of pharmacy and pharmacology  •  1993  |  View Paper
Because a number of compounds interfere with vitamin B6 and dopamine toxicity in animals is modified by B6 , we studied the dopamine-vitamin B6 interaction in rabbits.
Dopamine administration led to an average fall of 20% (p = 0.04) in plasma pyridoxal 5'-phosphate (PLP) levels, which declined 42% by day 5.
Dopamine with pyridoxine caused a PLP rise of 65% (p = 0.007), but the post-study level was 28% lower than baseline (p = 0.04).
We interpret our data to mean that dopamine reduced PLP levels during and 3 days after the study, and that dopamine appeared to increase the requirements for B6.
Veterinary and human toxicology  •  1991  |  View Paper
Administration of either Levodopa (l-DOPA) or pyridoxine increased the concentration of dopamine in the basal ganglia of rats.
Journal of neurochemistry  •  1972  |  View Paper
However, nonenzymatio studies under conditions similar to those of the … reveal that most of the inhibition by dopa, dopamine and norepinephrine is due to … of these compounds with pyridoxal phosphate while reaction between pyridoxal phosphate and the tryptophan derivatives, 5-… and serotonin, does not occur under the conditions employed.
Archives of biochemistry and biophysics  •  1972  |  View Paper