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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Dopamine
supplement:
St John's Wort
Research Papers that Mention the Interaction
“ St. John's wort extract has a clear inhibitory effect on the neuronal uptake not only of serotonin, noradrenaline, and dopamine but also of gamma-aminobutyric acid (GABA) and L-glutamate.”
Current St John's wort research from mode of action to clinical efficacy.“The sulfation of dopamine was inhibited by extracts of banaba, green tea, Rafuma, grape seed, peanut seed coat, gingko biloba leaf, St. John's wort , gymnema and milkthistle.”
“In addition, St. John's wort is a potent uptake inhibitor of the neurotransmitters serotonin, norepinephrine and dopamine all of which have a role in mood control.”
“In our previous investigations, we could demonstrate that extract preparations of Hypericum perforatum (St. John's wort, SJW) inhibit the uptake of several neurotransmitters (serotonin, norepinephrine, dopamine , GABA, L-glutamate) in synaptosomal preparations of rodent brain.”
Evaluation of synaptosomal uptake inhibition of most relevant constituents of St. John's wort.“ Hyperforin-free Hypericum extract also elevates the extracellular concentrations of dopamine and norepinephrine in the locus coeruleus, but, in contrast to hyperforin, the extracellular concentration of serotonin is diminished.”
“ Hypericum extract (Ph-50; 250-500 mg/kg) with acute oral administration enhanced serotonin, norepinephrine and dopamine content in the brain and reduced the immobility time of rats in the forced-swimming test.”
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