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Last Updated: 4 months ago

Possible Interaction: Dopamine and St John's Wort


St John's Wort

Research Papers that Mention the Interaction

CONCLUSIONS Taken together with data from animal experimental studies, the findings suggest that this dose of HP may increase some aspects of brain dopamine function in humans.
Biological Psychiatry  •  1999  |  View Paper
The sulfation of dopamine was inhibited by extracts of banaba, green tea, Rafuma, grape seed, peanut seed coat, gingko biloba leaf, St. John's wort , gymnema and milkthistle.
Biological & pharmaceutical bulletin  •  2009  |  View Paper
In addition, St. John's wort is a potent uptake inhibitor of the neurotransmitters serotonin, norepinephrine and dopamine all of which have a role in mood control.
Journal of ethnopharmacology  •  2005  |  View Paper
St. John's wort extract has a clear inhibitory effect on the neuronal uptake not only of serotonin, noradrenaline, and dopamine but also of gamma-aminobutyric acid (GABA) and L-glutamate.
Pharmacological research  •  2003  |  View Paper
Initial biochemical studies reported that St John’s wort is only a weak inhibitor of monoamine oxidase-A and -B activity but that it inhibits the synaptosomal uptake of serotonin, dopamine and noradrenaline (norepinephrine) with approximately equal affinity.
CNS drugs  •  2003  |  View Paper
In our previous investigations, we could demonstrate that extract preparations of Hypericum perforatum (St. John's wort, SJW) inhibit the uptake of several neurotransmitters (serotonin, norepinephrine, dopamine , GABA, L-glutamate) in synaptosomal preparations of rodent brain.
Pharmacopsychiatry  •  2001  |  View Paper
Hyperforin-free Hypericum extract also elevates the extracellular concentrations of dopamine and norepinephrine in the locus coeruleus, but, in contrast to hyperforin, the extracellular concentration of serotonin is diminished.
Pharmacopsychiatry  •  2001  |  View Paper
Hypericum extract (Ph-50; 250-500 mg/kg) with acute oral administration enhanced serotonin, norepinephrine and dopamine content in the brain and reduced the immobility time of rats in the forced-swimming test.
Pharmacopsychiatry  •  2001  |  View Paper
Administration of Hypericum perforatum extract (1 mg/kg, p.o.) caused a slight, but significant increase of DA outflow both in the nucleus accumbens and the striatum.
Pharmacopsychiatry  •  2000  |  View Paper