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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Dopamine
supplement:
Sapropterin
Research Papers that Mention the Interaction
“On the contrary, when we reduce R-THBP content in the tissues including the brain by use of … tissue content of dopamine and its metabolites very slightly decreased at around 10%, but such a treatment lowering R-THBP … dopamine release ; the dopamine output from the …% of the control level.”
“This result and other experimental data indicate that the endogenous level of R-THBP can regulate dopamine release.”
6R-[3H]tetrahydrobiopterin binding activities in rat brain.“Among various types of pterins, R-THBP has attracted researcher’s interest in recent years, since R-THBP regulates not only the biosynthesis but also the release of biogenic amines such as dopamine and serotonin1,2 and other neurotransmitters, glutamate2 and acetylcholine (ACh)3.”
“Perfusion of 1.0 mM R-THBP enhanced the level of dopamine output in dialysates collected from the striatum and frontal cortex.”
“These results suggest that R-THBP may play a role in the mechanisms of release of dopamine , serotonin, and glutamate.”
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