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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Dopamine
supplement:
S-Adenosylmethionine
Research Papers that Mention the Interaction
“ SAM may physiologically antagonize the effects of L-dopa and biochemically decrease the concentrations of L-dopa and dopamine.”
The effects of L-dopa on the activity of methionine adenosyltransferase: Relevance to L-dopa therapy and tolerance“Double the dose of AdoMet did not increase the depletion of DA on the ipsilateral CN, but DA in the contralateral CN was decreased by 26.3%.”
“Rapid-flow dialysis studies indicated a S-… of 0.65 - 10(-6) M. Dopamine appeared to interfere … binding of S-adenosylmethionine to the weanling rat liver protein preparation but did not affect the binding of … to protein in several systems in which dopamine did not inhibit tRNA methylase activity.”
“ DA interacted with β-CD based on intermolecular hydrogen bond and formed inclusion complexes in SAM , namely DA@β-CD/MUA SAM.”
“The decrease of negative charge density of SAM resulted in the weakening of hydrogen bond between DA and β-CD, which in turn caused DA to be released.”
Controllable release of dopamine from simulated enzyme-containing biomembrane by biased potential.
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