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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“The decrease in Isc evoked by dopamine was inhibited by bumetanide, an inhibitor of the basolateral Na+-K+-2 Cl− cotransporter responsible for the uptake of K+, and by quinine , a blocker of apical K+ channels, indicating that stimulation of K+ secretion contributes to the measured change in Isc.”
Effects of dopamine on ion transport across the rat distal colon“A local application of ATP-sensitive K+ (KATP) channel blocker, quinine (10 microM, 100 microM, 1 mM), produced dose-dependent increases in extracellular concentrations of dopamine.”
“ Quinine (100 microM, 1 mM) significantly blocked a 7-OH-DPAT-induced decrease in the striatal dopamine levels in the dose-dependent manner.”
“… quinine and quinidine also inhibited the active …]5-HT, [3H]noradrenaline and [3H]dopamine into rat brain synaptosomes with IC50 values in the range 0.13-12.4 microM. The potency of … to inhibit [3H]5-HT uptake was significantly higher than that for [3H]noradrenaline or [3H]dopamine.”
“Local application of the D2 receptor antagonist (-)-sulpiride (SLP, 10(-5) M) or the KATP channel blocker quinine (QIN, 10(-3) M) produced significant increases in extracellular concentrations of DA.”
“Local perfusion with quinine , a K+ channel blocker, completely blocked the (—)‐sulpiride‐induced increases in DA but did not affect the DA agonist‐induced decreases.”
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