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Last Updated: a year ago

Possible Interaction: Dopamine and Phenylalanine



Research Papers that Mention the Interaction

High Phe concentrations interfere with the production of adrenaline (A), noradrenaline (NA), and dopamine (DA) (1)(3).
Clinical chemistry  •  2002  |  View Paper
Under these study conditions, phenylalanine and tyrosine depletion may have larger effects on dopamine than noradrenaline.
Journal of psychiatry & neuroscience : JPN  •  2001  |  View Paper
High levels of phenylalanine (Phe) have been shown to reduce dopamine (DA) and noradrenaline (NA) production.
Clinical endocrinology  •  1998  |  View Paper
Increased brain phenylalanine concentration likely competitively inhibits the activities of tyrosine hydroxylase (TH) and tryptophan hydroxylase (TPH), the rate limiting steps in dopamine and serotonin synthesis respectively.
Molecular genetics and metabolism  •  2016  |  View Paper
The excess of phenylalanine blocks the transport of important amino acids to the brain contributing to reduced levels of dopamine and serotonin.
Folia neuropathologica  •  2013  |  View Paper
BackgroundIt has been previously postulated that high phenylalanine (Phe) might disturb intracerebral dopamine production, which is the main regulator of prolactin secretion in the pituitary gland.
European Journal of Medical Research  •  2016  |  View Paper
In 12 healthy volunteers performing a Simon task, dopamine availability was reduced with an amino acid drink deficient in the dopamine precursors, phenylalanine and tyrosine.
Psychopharmacology  •  2014  |  View Paper
As a result of this situation, the phe levels rise up to 800–1000 μmol/L. In addition, there is some convincing evidence that the conversion of tyrosine (tyr) to melanin, dopamine and norepinephrine is decreased by high blood concentrations of phenylalanine (Nadler and Hsai, 1961).
Journal of Inherited Metabolic Disease  •  2013  |  View Paper
The impaired conversion of phenylalanine may affect not only the production of tyrosine but also the biosynthesis of the neurotransmitters dopamine , norepinephrine and epinephrine.
Journal of the Neurological Sciences  •  2013  |  View Paper
Fifteen years later, when early treatment of PKU with a phenylalanine restricted diet was routinely introduced, an inverse relationship was found between phenylalanine levels and the urinary excretion of dopamine and serotonin.
Journal of Inherited Metabolic Disease  •  2005  |  View Paper
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