Possible Interaction: Dopamine and Phenethylamines

“It functions as an activator for the neurotransmission of dopamine and other catecholamines, and very low concentrations of PEA may be associated with specific psychological disorders such as ADHD.”

“Platelet monoamine oxidage-B activity is increased by the use of phenylethylamine but decreased by the use of dopamine as substrate.”

“ Phenylethylamine administration influences other neurotransmitters such as dopamine , norepinephrine and 5-hydroxytryptamine.”

“Other studies have shown that phenylethylamine is an endogenous precursor-neurotransmitter capable of modulating the activity of dopamine.”

“These trace amines, including phenethylamine , phenylethanolamine, tyramine and octopamine, are derived from phenylalanine and tyrosine, which are normally metabolized in the liver, and may interfere with neural transmission of noradrenaline and dopamine in the central and peripheral nervous systems [l].”

“The phenethylamine derivatives , 4-fluoroamphetamine, 2-methylamino-3,4-methylene-dioxy-propiophenone (methylone), 1-(1,3-benzodioxol-5-yl)-2-butanamine (BDB), and N-methyl-1-(1,3-benzodioxol-5-yl)-2-butanamine (MBDB), had strong inhibitory effects on the re-uptake of dopamine , 5-HT and norepinephrine.”

“It is believed that the locomotor‐stimulating action of β‐PEA , much like amphetamine, depends on its ability to increase extracellular dopamine ( DA ) concentrations owing to reversal of the direction of dopamine transporter (DAT)‐mediated DA transport.”

“ DA was released by phenylethylamine at rates significantly greater than its basal rate.”

“The results suggest (1) that phenylethylamine may exert its behavioural effects through increased release of both DA and 5-HT, and (2) that in vivo measurements of the acid metabolites alone may not be indicative of the release of the amines.”

“At 7 min, MAO activity towards dopamine was enhanced by 32% and that towards serotonin and phenylethylamine ( PEA ) was decreased by 23 and 25%, respectively.”

“4 Administration of CEPEA caused more prolonged decreases in brain noradrenaline, dopamine and 5‐hydroxytryptamine concentrations than those observed after PEA administration, although values increased to control levels eventually.”