Possible Interaction: Dopamine and Methionine

“Morphological studies showed … intraperitoneal injections of dopamine in doses of …–2 and 10–1 M down-regulates the general number of cells in the Ehrlich ascites carcinoma in 10 and 30 times … decreases their diameter by 27% and 59%, respectively (as compared to the control animals received physiological saline).”

“The higher concentrations of propranolol (10−7 and 10−6 M ) unmasked the contractile effect of DA.”

“ Dopamine typically decreased spontaneous midgut activity at doses of 10−8 M or greater, and produced inhibitory actions on all regions of the Limulus midgut.”

“Monensin addition 10−3 M ) reversed the inhibitory effect of dopamine after a 30-min preincubation.”

“ Dopamine elevation reduced in vitro incorporation of methionine into proteins synthesized in brain CNS.”

“ Dopamine at concentrations over 10−5 M induced contractions of tracheal muscle strips and repeated exposures resulted in desensitization (tachyphylaxis) of the muscle.”

“At 10−t M, dopamine prevented the increase in calcium concentration caused by 10−9 M TRH, and partially inhibited the increase caused by higher concentrations of the peptide.”

“ Dopamine decreased the control efflux rate, prevented the rise caused by thyroliberin ( 10−7 M ) in the presence of 3‐isobutyl‐l‐methyl‐xanthine (10−4 M) and greatly decreased the rise caused by acetylcholine (2.5 × 10−5 M).”

“Abstract Dopamine stimulated and dopaminergic antagonist·inhibited the enzymic synthesis of phosphatidyl N-monomethyl, N,N-dimethyl ethanolamine and phosphatidylcholine in mouse B lymphocytes in the presence of L-methionine.”

“A DOP dose of 10-5 M significantly increased RR while a higher (10-3 M) dose significantly stimulated both RR and cAMP content in the slice preparation.”