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Last Updated: 4 months ago

Possible Interaction: Dopamine and Melatonin

supplement:

Melatonin

Research Papers that Mention the Interaction

The antagonism of melatonin in models of Parkinson's disease (PD) can reduce the severity of motor impairment associated with dopamine (DA) degeneration.
Chronobiology international  •  2007  |  View Paper
Plasma norepinephrine and dopamine levels in the supine position 60 minutes after melatonin administration were lower compared with placebo (P <.05 and P <.01, respectively).
American heart journal  •  2001  |  View Paper
There is some evidence in animals that dopamine DA ) affects melatonin secretion.
Progress in Neuro-Psychopharmacology and Biological Psychiatry  •  1987  |  View Paper
Some experimental studies reported the attenuation of 5-HIAA and dopamine level in the brain with melatonin administration.
Developmental medicine and child neurology  •  2012  |  View Paper
Past studies in rodents have demonstrated circannual variation in central dopaminergic activity as well as a host of compelling interactions between melatonin --a scotoperiod-responsive neurohormone closely tied to seasonal adaptation--and dopamine in the striatum and in midbrain neuronal populations with striatal projections.
The Journal of neuroscience : the official journal of the Society for Neuroscience  •  2010  |  View Paper
In addition, the reduction of phosphorylation of tyrosine hydroxylase, the rate limiting enzyme in dopamine synthesis, and phosphorylation of cyclic AMP responsive element-binding protein by H(2)O(2) and MPP(+) was also diminished by melatonin.
Journal of pineal research  •  2009  |  View Paper
We discuss the results in … mutually inhibitory systems of melatonin … dopamine , and find further support for a hypothesis that it is the variation in the length of photoperiod during the … perinatal period that contributes significantly to the season of birth variation found in the morningness-eveningness preference among adults.
Neuropsychobiology  •  2002  |  View Paper
Dopamine turnover is likely associated with NS, and the mutually inhibitory systems of dopamine and melatonin are the paracrine signals of day and night, respectively.
Psychiatry Research  •  2002  |  View Paper
Dopamine is considered a natural downregulator of seizure activity in a number of species, including humans, and numerous lines of evidence suggest that melatonin is capable of stimulating a decrease in dopamine output within areas of the brain thought to participate in the control of epileptic seizures.
The International journal of neuroscience  •  2001  |  View Paper
Exposure to dopamine (10 microM) or L-DOPA (100 microM) markedly diminished the forskolin-stimulated release of melatonin , as well as the production of 5-hydroxytryptophan and serotonin.
The inhibition of melatonin release by dopamine supports the hypothesis that in these cells, melatonin and dopamine are components of a retinal feedback loop.
Brain Research  •  1991  |  View Paper
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