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Last Updated: 2 years ago

Possible Interaction: Dopamine and Manganese

supplement:

Manganese

Research Papers that Mention the Interaction

Manganese produces a Ca2+ channel-mediated current, which increases neurotransmitter release and rhythmic firing activity of dopamine neurons.
We found that manganese concentration-dependently increased the excitability of dopamine neurons, decreased the amplitude of action potentials, and narrowed action potential width.
The Journal of Neuroscience  •  2020  |  View Paper
Moreover, combined treatment of Mn and DA also increased Nestin expression level.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan  •  2014  |  View Paper
Dr. Guilarte's experimental, non-human primate model of Mn neurotoxicity suggests that Mn decreases dopamine release in the brain without loss of neuronal integrity markers, including dopamine.
Neurotoxicology  •  2012  |  View Paper
Several in vivo and in vitro studies have linked increased manganese concentrations with alterations in the content and metabolism of neurotransmitters, namely dopamine , gamma-aminobutyric acid, and glutamate.
Neurochemistry International  •  2003  |  View Paper
Therefore, the decreased availability or autoxidation of dopamine attenuated manganese neurotoxicity.
Brain Research  •  1988  |  View Paper
Previous work indicated that Mn was more potent than other transition metal ions at stimulating dopamine (DA) auto-oxidation.
Neurotoxicology  •  1987  |  View Paper
Dopamine serves as a tonic inhibitor of prolactin release in the anterior hypophysis, thus the serum prolactin levels in occupationally Mn exposed workers has been found increased.
Environmental research  •  2011  |  View Paper
These results showed that Mn suppresses the inhibitory feedback control of DA on the hypophyseal-pituitary axis.
Neurotoxicology  •  2007  |  View Paper
Manganese and DA (200 microM), although not cytotoxic when individually administered to SK-N-SH cells, had a synergistic action on cytotoxicity.
These results suggest that DA toxicity is tightly linked to intracellular oxidant/antioxidant levels, and that environmental factors, such as excessive Mn exposure, may modulate cellular sensitivity to DA.
Brain Research  •  2000  |  View Paper
Moreover, flies treated with Mn exhibited a significant decrease in dopamine levels and in tyrosine hydroxylase activity, as well as in mitochondrial and cellular viability.
Environmental Science and Pollution Research  •  2021  |  View Paper
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