Possible Interaction: Dopamine and Iron, Dietary

“This emphasizes the close relationship between iron and DA , two key chemical components, and thus a toxic couple in the degeneration of dopaminergic neurons [5].”

“In this Update, we explain that neurodegeneration in the affected regions may result from the potent redox couple formed by iron and dopamine itself, and discuss the clinical implications of this molecular trait in this dynamic and rapidly moving area of Parkinson's disease research.”

“Combined treatments of Fe with Mn or DA also tended to increase Emx2 expression level.”

“A new study shows that mice lacking tau develop parkinsonism because of intracellular iron accumulation that results in degeneration of dopamine neurons.”

“However, the way dopamine and iron , and probably other compounds, interact to generate the circadian pattern in the occurrence of RLS and PLM symptoms remains unknown.”

“MPP(+) is a highly potent dopaminbergic-releasing agents and dopamine (DA) autoxidation catalyzed by iron and oxidative stress may be involved in the pathogenesis of Parkinson's disease.”

“Following injection of iron in rat brains, a relatively selective lesion of dopamine neurons, similar to parkinsonism, occurs.”

“ Iron may increase the cytotoxicity of neuronal dopamine by increasing its rate of oxidation to quinones and semiquinones, thereby reducing the level of this neurotransmitter.”

“ Dopamine can auto-oxidize to produce free radicals particularly in the presence of iron and other heavy metals.”

“The combination of high concentration of iron and the neurotransmitter, dopamine , may contribute to the selective vulnerability of the SNpc.”

“The latter is further supported by our recent findings that intranigral injection of iron (50 μg) resulted in a substantial selective decrease of striatal dopamine (95%) and impaired dopamine‐related responses.”