Possible Interaction: Dopamine and Glycine

“The affinity of the receptor for dopamine is significantly higher in the case of genotypes containing the Gly allele ( Gly (+) compared with the Ser/Ser genotype (Lundstrom and Turpin, 1996).”

“The replacement of Arg by Gly reduced the inhibitory effect of dopamine on the catalytic activity measured in the basic pH range and the replacement of Arg by Glu was enough to abolish the inhibitory effect, although these mutations brought no significant changes to the circular dichroism spectrum.”

“Furthermore, DPP, … and GL enhanced the … of dopamine , brain‑derived neurotrophic factor and phosphorylated-extracellular signal‑regulated kinase in the brains of mice with treadmill exercise‑induced exhaustive fatigue, and decreased levels of certain proinflammatory cytokines in the serum and spleen, as determined by ELISA and western blot analysis.”

“The glycineB agonists glycine (1 mM) and D-serine (10 microM), but not D-cycloserine (10 microM), substantially increased the spontaneous release of dopamine , but significantly reduced the release of dopamine evoked by NMDA.”

“Our data also raise the possibility that glycine could increase dopamine output from the VTA by a mechanism of disinhibition.”

“ Glycine and GDA significantly inhibit NMDA-induced striatal dopamine release , consistent with their ability to enhance local striatal inhibitory neurotransmission in vitro and to reverse PCP-induced hyperactivity in vivo.”

“This observation and the fact that MPTP/MPP+ causes the loss of nigrostriatal GSH without corresponding increases of glutathione disulfide (… results of the present investigation suggest that the release and γ‐GT/dipeptidase‐mediated hydrolysis of GSH to glutamate, glycine , and CySH may be … with the degeneration of dopamine ….”

“In addition, glycine increased the evoked release of [3H]‐dopamine via a site inhibitable by strychnine (1 μM).”

“Exogenous glycine inhibited light-stimulated dopamine release in a concentration-dependent and strychnine-sensitive manner.”

“3 Glycine administered via the microdialysis probe dose‐dependently increased concentrations of dopamine and its metabolites, dihydroxyphenylacetic acid and homovanillic acid, in the perfusate, indicating increased local release and metabolism of dopamine.”