Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 4 months ago

Possible Interaction: Dopamine and Glutathione

supplement:

Glutathione

Research Papers that Mention the Interaction

There was a 400-600-fold increase in urine dopamine output after gludopa ; there was no conversion of glutyrosine to dopamine.
Clinical science  •  1988  |  View Paper
Notably, dopamine reduced erastin-induced ferrous iron accumulation, glutathione depletion , and malondialdehyde production.
Biochemical and biophysical research communications  •  2016  |  View Paper
Similarly the 1321N1 human astrocytoma cell line was found to increase GSH release in response to 50μM dopamine.
The SH-SY5Y human neuroblastoma cell line was found to increase intracellular GSH levels in response to 50μM dopamine treatment.
Neurochemistry International  •  2013  |  View Paper
Conversely, the CuAbeta-catalyzed oxidation reaction of dopamine is inhibited by bio-available reducing agents such as ascorbate (competitive K(ic)=66 microM) and glutathione (non-competitive, K(inc)=53 microM).
Biochimica et biophysica acta  •  2009  |  View Paper
GSH plays a fundamental role in protecting cells from damage by reactive oxygen species generated among others by the metabolism of dopamine.
The European journal of neuroscience  •  2000  |  View Paper
In macrophage cultures, glutathione (GSH) was upregulated strongly after treatment with dopamine , morphine or selegiline, and this effect was enhanced when cells were pre-exposed to virus.
Journal of neurovirology  •  1997  |  View Paper
Apoptosis, induced by 0.1-0.3 mM dopamine , was blocked by glutathione in a dose- and time-dependent manner.
Dopamine decreased glutathione levels within 16-24 hr; however, this effect was preceded by a transient increase in the level of the tripeptide within the first 0.5-7 hr.
Neuropharmacology  •  1996  |  View Paper
Alcohol, dopamine , and morphine, can alter intracellular levels of glutathione (GSH)-based cellular redox status, subsequently affecting SAM levels and DNA methylation status.
Front. Neurosci.  •  2014  |  View Paper
The inhibitory effects of dopamine were reduced greatly by the antioxidants ascorbate and glutathione , suggesting the involvement of reactive oxygen species in dopamine-mediated toxicity.
Journal of biomolecular screening  •  2010  |  View Paper
The glutathionyl and cysteinyl adducts of dopamine inhibited dopamine-mediated DNA damage indicating that these adducts may have antioxidant properties.
Free radical biology & medicine  •  1999  |  View Paper
Show More