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Last Updated: 4 months ago

Possible Interaction: Dopamine and Glutamate



Research Papers that Mention the Interaction

DA significantly enhanced the Glu uptake in primary cultured astrocyte supernatants.
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology  •  2017  |  View Paper
Our findings imply that dopamine regulates the availability of l-glutamate in the developing striatum.
Journal of Molecular Neuroscience  •  2009  |  View Paper
The cytotoxic effects of dopamine and L-glutamate were additive rather than synergistic, regardless of the incubation time used.
Neurochemistry International  •  1999  |  View Paper
In the absence of Mg2+, dopamine at 200 microM (IC50 60 microM), inhibited in more than 50% the release of [3H]GABA induced by L-glutamate and NMDA, but not by kainate.
European journal of pharmacology  •  1998  |  View Paper
In control rats the L-glutamate elicited responses of six cells tested could be suppressed by dopamine whereas in lesioned rats three of the six cells tested were unresponsive to dopamine.
Neuroscience  •  1996  |  View Paper
The enhancement of DA release elicited by pretreatment with L-glutamate was also impaired in the rats exposed to 5 min of ischemia.
Brain Research  •  1995  |  View Paper
Micromolar … of L-glutamate , as well as agonists that specifically activate N-methyl-D-… (NMDA) and non-NMDA receptors, are all toxic to dopamine neurons in a concentration-dependent manner, as reflected by decreases in high-affinity … uptake and confirmed by decreases in numbers of tyrosine hydroxylase-immunoreactive neurons.
Journal of neurochemistry  •  1995  |  View Paper
After incubation of the cells with dopamine for 3 min, the desensitization was significantly reduced and the agonists L-glutamate , quisqualate, or alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid induced steady-state currents with amplitudes that were similar to the previously observed transient currents.
Proceedings of the National Academy of Sciences of the United States of America  •  1994  |  View Paper
Both ASP and GLU produced a release response at a concentration range of 1 to 10 mM. GLU was generally less efficacious in increasing dopamine outflow; at 5 and 10 mM, the maximum effect exerted by GLU was significantly less than that observed with ASP.
The Journal of pharmacology and experimental therapeutics  •  1993  |  View Paper
Dopamine (DA) almost completely inhibited the K(+)-evoked release of Asp and Glu in a concentration-dependent manner, but the release of GABA was only partly inhibited.
The Journal of pharmacology and experimental therapeutics  •  1991  |  View Paper
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