Possible Interaction: Dopamine and Glucose

“These results are discussed in relation to our previous observation that D-glucose administration suppresses the firing of central dopamine-containing neurons.”

“The ratio of circulating growth hormone to glucose and the ratio of glucagon to glucose were greater during dopamine ( P = 0.045 and 0.037, respectively).”

“Inhibition experiments showed that dopamine was able to interact with glucose carriers only when conjugated to glucose (IC(50)=2.6+/-0.6mM).”

“We have previously demonstrated that dopamine conjugation to glucose allows it to induce therapeutic effects against Parkinson's disease after intravenous administration.”

“Simultaneous infusion of glucose prevented the inhibitory effect of dopamine infusion on plasma TSH.”

“Data from the radioimmunoassay indicated that dopamine inhibited insulin secretion in a glucose- and dose-dependent manner.”

“These results indicate that glucose activates vagal control of hyperglycemia and inflammation in fasted septic mice via dopamine.”

“Specifically, intragastric infusions of glucose induced significantly higher levels of dopamine release compared with isocaloric serine in both ventral and dorsal striatum.”

“These results underscore the potential importance of nutritional status (e.g., glucose and insulin) in modulating dopamine neurotransmission and in so doing they begin to establish a neurochemical link between the high co-morbidity of eating disorders and drug abuse.”

“SummaryAdministration of various doses of glucose to rats produced a significant decrease of dopamine turnover in both striatum and olfactory tubercle.”

“The higher concentrations of dopamine (10‐7 ‐ 10‐4) inhibited glucose‐induced insulin secretion in the presence of both 4 mM and 20 mM glucose.”