Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
“At high DA:Fe(II) ratios, the results from this study suggest that DA plays a protective role by complexing Fe(II ) and preventing it from reacting with the generated H2O2.”
“At low DA:Fe(II) ratios however, it is likely that DA will act as a pro‐oxidant by generating H2O2 which, in the presence of Fe(II ), will result in the production of strongly oxidizing •OH radicals.”
“The oxidation of DA resulted in the generation of significant amounts of H2O2 with this process accelerated significantly in the presence of Fe(II) and Fe(III).”
“On the basis of these data we have calculated that the binding affinities ofl-Phe, BH2, and dopamine decrease by 28-, 47-, and 5040-fold, respectively, for the reduced ferrous form of the enzyme, with respect to the ferric form.”