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Last Updated: 2 years ago

Possible Interaction: Dopamine and Ferrous

supplement:

Ferrous

Research Papers that Mention the Interaction

At high DA:Fe(II) ratios, the results from this study suggest that DA plays a protective role by complexing Fe(II ) and preventing it from reacting with the generated H2O2.
At low DA:Fe(II) ratios however, it is likely that DA will act as a pro‐oxidant by generating H2O2 which, in the presence of Fe(II ), will result in the production of strongly oxidizing •OH radicals.
The oxidation of DA resulted in the generation of significant amounts of H2O2 with this process accelerated significantly in the presence of Fe(II) and Fe(III).
Journal of neurochemistry  •  2016  |  View Paper
On the basis of these data we have calculated that the binding affinities ofl-Phe, BH2, and dopamine decrease by 28-, 47-, and 5040-fold, respectively, for the reduced ferrous form of the enzyme, with respect to the ferric form.
The Journal of Biological Chemistry  •  2001  |  View Paper
The addition of dopamine or H2O2 oxidizes the ferrous iron of the native human TH to the ferric state.
European journal of biochemistry  •  1996  |  View Paper