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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
drug:
Dopamine
supplement:
Cupric Cation
Research Papers that Mention the Interaction
“This implies that oligomerization invoked by DA is reversible in the presence of Cu2+ , which appears to be mediated by noncovalent bond interactions.”
Dopamine and Cu+/2+ can induce oligomerization of α‐synuclein in the absence of oxygen: Two types of oligomerization mechanisms for α‐synuclein and related cell toxicity studies“ Dopamine induced strand breaks and base oxidation in calf thymus DNA in the presence of Cu(II) or Fe(III)-NTA (nitrilotriacetic acid).”
Different Mechanisms Between Copper and Iron in Catecholamines-Mediated Oxidative DNA Damage and Disruption of Gene Expression In Vitro“Therefore, it is concluded that oxidative DNA damage induced by dopamine in the presence of Mn(II), NADH, and Cu(II) is possibly linked to the degeneration of dopaminergic neurons.”
“Ferric or cupric ion significantly promoted a peroxidative cleavage in liposomes (model membranes) after coordinating with dopa or dopamine.”
“Binding of [3H]dopamine is also increased by Cu2+ and Mn2+, but to a lesser extent than by Fe2+.”
“Binding of [3H]dopamine is greatly enhanced by Fe2+, Cu2+ and Mn2+, but not by Fe3+.”
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