Possible Interaction: Dopamine and Calcium Supplement

“3 Activation of either D2 or D4 receptors by dopamine (10 μm) or quinpirole (0.1 to 10 μm) reduced the peak calcium current by ca.”

“In different types of neurone, activation of ~-adrenergic, GABAB, adenosine A~, dopamine , 5-HT,/~, 6and x-opioid, muscarinic acetylcholine, neuropeptide Y and somatostatin receptors results in inhibition of Ca 2÷ currents (for review see Tsien et al., 1988).”

“Several neurotransmitters (noradrenaline, GABA, 5 HT and dopamine ) all inhibit Ca 2÷ currents recorded from chick sensory neurones, this shows convergence of receptor mechanisms onto a single effector, the Ca 2+ channel.”

“There was an association between increased cortisol and increased CAC and an inverse association between dopamine and CAC.”

“Daily urinary excretion of free dopamine , sodium clearance (CNa), fractional excretion of sodium (FENa), and urinary volume were significantly increased by oral calcium supplementation.”

“The intravenous application of 4 micrograms/kg/min dopamine (DA) over 3 h in 11 healthy volunteers resulted in an increase in inulin clearance and urine volume by about 10%, renal excretion of sodium and calcium being increased by DA by a factor of 5.”

“The addition of dopamine or somatostatin to low calcium medium further decreased PRL release.”

“These results indicate that following D1-like-receptor binding, dopamine selectively induces transient elevations in intracellular calcium via activation of IP3 and ryanodine receptors, and that these elevations are linked to the facilitation of synaptic responses in putative layer II entorhinal cortex fan cells.”

“In order to elicit the CaMKII/PP1-dependent response, the calcium and dopamine inputs should arrive in temporal proximity and must follow a specific (dopamine after calcium) order.”

“In addition, it highlighted the possible dependency of dopamine effects on intracellular calcium and signified potential interaction among dopamine and nicotine.”

“ Dopamine has been shown to modulate calcium current in DRG neurons, but the effects of dopamine on sodium current and on the firing properties of small DRG neurons are poorly understood.”