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Discover Supplement-Drug Interactions

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Last Updated: 4 months ago

Possible Interaction: Domperidone and Silymarin

supplement:

Silymarin

Research Papers that Mention the Interaction

Conclusions: The significant difference in absorption of domperidone on pretreatment with silymarin is due to the inhibition of P-glycoprotein and CYP3A.
Silymarin , which inhibits CYP3A4, should be contraindicated for domperidone.
The silymarin pretreatment increased the bioavailability of domperidone.
Drug metabolism and drug interactions  •  2014  |  View Paper