Possible Interaction: Domperidone and Quinidine

“Following changes were … action); quinidine … domperidone promotes growth of its concentration in plasma; analysis of changes in the value of AUC(0-2) at the initial three weeks … hepatic biotransformation and the mechanism of induction of absorption during domperidone administration is different from the absorption - inducing effects of quinidine.”

“In addition, QD significantly increased the DOM AUC(0-2) (32%), whereas 19% increase was observed after GFJ extract administration.”

“In conclusion, GFJ and QD significantly influenced DOM rat plasma concentration during the first two hours after DOM administration indicating that interaction takes place during absorption phase.”

“The GFJ extract and QD administration significantly increased c(max) of DOM by 19% and 36%, respectively, and the AUC(0-0.25) (area under the concentration-time curve from time zero to 15 min) by 29% and 44%, respectively.”