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Last Updated: 3 years ago

Possible Interaction: Dolastatin 10 and Celecoxib

supplement:

Dolastatin 10

drug:

Celecoxib

Research Papers that Mention the Interaction

“A combinatorial strategy of using Cyclooxygenase-2 inhibitor, Celecoxib and Dolastatin , a linear peptide from marine mollusks of Indian Ocean origin has shown anti-neoplastic effects in colon cancer in a rat model.”
Dolastatin, along with Celecoxib, stimulates apoptosis by a mechanism involving oxidative stress, membrane potential change and PI3-K/AKT pathway down regulation.
Biochimica et biophysica acta  •  2013  |  View Paper
“However, a simultaneous treatment with Celecoxib and Dolastatin 15 decreases such number to a significant level.”
Up‐regulation of p53 and mitochondrial signaling pathway in apoptosis by a combination of cox‐2 inhibitor, celecoxib and dolastatin 15, a marine mollusk linear peptide in experimental colon carcinogenesis
Molecular carcinogenesis  •  2013  |  View Paper
“Simultaneous administration of Celecoxib and Dolastatin reduced these features significantly.”
Dolastatin 15, a mollusk linear peptide, and Celecoxib, a selective cyclooxygenase-2 inhibitor, prevent preneoplastic colonic lesions and induce apoptosis through inhibition of the regulatory transcription factor NF-&kgr;B and an inflammatory protein, iNOS
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation  •  2012  |  View Paper