Possible Interaction: Docosahexaenoic Acid and Sorafenib

“ConclusionsWe demonstrate that sorafenib attenuates DHA-induced HO-1 expression and acts in synergy with DHA to suppress cancer cell viability and tumor growth.”

“Screening of the NCI-Oncology Drug Set IV identified a group of anticancer compounds, including Sorafenib , which enhanced DHA ’s cytotoxicity, as well as a set of compounds that attenuated DHA’s cytotoxicity.”

“ Sorafenib acted synergistically with DHA to suppress cancer cell viability in various human cancer cell lines and suppressed tumor xenograft growth in mice fed a fish oil enriched diet (high n-3/DHA), as compared to mice fed a corn oil (high n-6) diet.”