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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Docosahexaenoic Acid and Sorafenib

Research Papers that Mention the Interaction

ConclusionsWe demonstrate that sorafenib attenuates DHA-induced HO-1 expression and acts in synergy with DHA to suppress cancer cell viability and tumor growth.
Screening of the NCI-Oncology Drug Set IV identified a group of anticancer compounds, including Sorafenib , which enhanced DHA ’s cytotoxicity, as well as a set of compounds that attenuated DHA’s cytotoxicity.
Sorafenib acted synergistically with DHA to suppress cancer cell viability in various human cancer cell lines and suppressed tumor xenograft growth in mice fed a fish oil enriched diet (high n-3/DHA), as compared to mice fed a corn oil (high n-6) diet.
BMC Cancer  •  2018  |  View Paper