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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Docetaxel and St John's Wort

supplement:

St John's Wort

Research Papers that Mention the Interaction

Hypericum extract , by inducing both the CYP3A4 and the P-glycoprotein (P-gp), can reduce the plasma concentrations of different antineoplastic agents such as imatinib, irinotecan and docetaxel , thus reducing the clinical efficacy of these drugs.
Current drug metabolism  •  2011  |  View Paper
This implies that subtherapeutic docetaxel concentrations may result when docetaxel is administered to patients using St. John's wort on a chronic basis.
Clinical Cancer Research  •  2005  |  View Paper