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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Dobutamine
supplement:
Vitamin C
Research Papers that Mention the Interaction
“Conclusions —The administration of the antioxidant vitamin C augments the inotropic response to dobutamine in humans.”
“The infusion of vitamin C augmented the LV +dP/dt response to dobutamine by 22±4% (Dob, 1680±76 mm Hg/s; Dob+vit C, 1814±97 mm Hg/s, P <0.01).”
“Dear Editor, We read with interest the excellent study by Shinke et al, whereby the investigators showed that adjunct acute doses of vitamin C enhance the contractile response to dobutamine in postinfarcted heart failure patients.”
“The … of vitamin C augmented the E(es) response to dobutamine by 20% +/- 8% (Dob 2.1 +/- 0.3, Dob + Vit C 2.5 +/- 0.4 mm Hg/mL, P < .01) and the SW/MVO2 response by 21% +/- 5% (Dob 36% +/- 3%, Dob + Vit C 43% +/- 4%, P < .01).”
“The infusion of vitamin C augmented the LV +dP/dt response to dobutamine by 22 +/- 4% in the NLV function group.”
“The peak positive rate of change of LV pressure (LV +dP/dt) was measured in response to the intravenous infusion of dobutamine before and during the intracoronary infusion of vitamin C (96 mg/min).”
Redox modulation of the inotropic response to dobutamine is impaired in patients with heart failure.
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