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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Dobutamine
supplement:
Epinephrine
Research Papers that Mention the Interaction
“However, when epinephrine (10‐6 M) and dobutamine were combined, dobutamine reduced cAMP production at concentrations between 10‐6 to 10‐4 M (P = 0.001).”
“In addition, the isobolographic analysis for equieffective concentrations of dobutamine and epinephrine suggests subadditive effects.”
“The authors hypothesized that combinations of dobutamine and epinephrine would produce additive biochemical and hemodynamic effects.”
“These findings suggest that combinations of dobutamine and epinephrine may be less than additive.”
Dobutamine Antagonizes Epinephrine's Biochemical and Cardiotonic Effects: Results of an In Vitro Model Using Human Lymphocytes and a Clinical Study in Patients Recovering from Cardiac Surgery“Inhibition of chemiluminescence of neutrophils by EPI was approximately 100-fold more potent than that by DA and DOB.”
“Conclusion: The present study showed that the use of epinephrine and dobutamine was associated with significantly increased in-hospital mortality in patients with septic shock.”
“The effects of epinephrine and dobutamine were time- and dose-dependent.”
“The use of epinephrine and dobutamine was associated with significantly higher in-hospital mortality (epinephrine, hazard ratio [HR]: 4.79, 95% confidence interval [CI]: 2.12-10.82, P = .001; dobutamine, HR: 2.53, 95% CI: 1.30-4.95, P = .046).”
“However, her haemodynamic stability deteriorated, despite increasing doses of epinephrine and dobutamine.”
“The response to the combination of dobutamine and epinephrine was 151% to 565% of the expected response.”
“The clearance rates of two other inotropic catecholamines, dopamine and dobutamine , are significantly correlated with the clearance rate of epinephrine. (”
“On the other hand, while the higher dose … drugs significantly increased heart rate (HR), epinephrine from 88 +/- 2 at baseline to 90 +/- 2 beats/min and dobutamine from 89 +/- … baseline to 105 +/- 3 beats/min, the increase following the higher dose of dobutamine was significantly greater … seen after epinephrine.”
“ Dobutamine inhibited the vesicular uptake of a mixture of 70% adrenaline + 30% 3H-noradrenaline into ghosts, with an IC50 of 1.7 μmol/l.”
The effect of (±)-dobutamine on adrenergic nerve endings“… adrenaline , the relaxation in …·l−1 dobutamine was larger than that to 2.7 μmol·l−1 terbutaline both in proximal and distal portions, while when it was … to terbutaline was larger than that to dobutamine in the proximal portion; in the distal portion, dobutamine and terbutaline were equieffective.”
“ Dobutamine and dopexamine were about 500-fold less active than epinephrine in suppressing peristalsis.”
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