Possible Interaction: Dobutamine and Calcium Supplement

“ Calcium reduced the increase in cardiac output produced by dobutamine by 30 percent, but it did not alter the cardiotonic actions of amrinone.”

“Currently available inotropes, such as dobutamine and milrinone, increase cardiac contractility at the expense of increased intracellular concentrations of calcium and cAMP, contributing to increased heart rate, hypotension, arrhythmias, and mortality.”

“There was a significant correlation between the CAC score and dobutamine CMR (p<0.001).”

“Clinicians should recognize that in certain circumstances, calcium may interact negatively with catecholamines such as epinephrine or dobutamine.”

“Also, the action of dobutamine was related to the increase of calcium ions and diminished by chelating intracellular calcium.”

“ResultsDeveloped pressure was significantly higher with dobutamine compared to high perfusate calcium of 3.5 mM (73 ± 10 vs 63 ± 10 mmHg, p < 0.05), though peak systolic intracellular calcium was not significantly different, suggesting reduced myofilament responsiveness to intracellular calcium with high perfusate calcium.”

“The ratio of developed pressure to myocardial oxygen consumption, … index of economy of contraction, was significantly increased with dobutamine compared to high perfusate calcium (1.35 ± 0.15 vs 1.15 ± 0.15 mmHg/μmoles/min/g dry wt, p < 0.05), suggesting energetic inefficiency with high perfusate calcium.”

“ Dobutamine caused more marked increases in [ Ca ] than did terbutaline.”