Possible Interaction: Disulfiram and Tretinoin

“Furthermore, an inhibitor of RA synthesis, disulphiram , disrupts alveologenesis.”

“Blockade of RA synthesis with disulfiram inhibited RA-induced transcription and produced hearts lacking the atrial chamber.”

“Both beta-apo-carotenal and retinoid production from beta-carotene were inhibited completely by adding disulfiram , an inhibitor of sulfhydryl-containing enzymes.”

“On the other hand, inhibition of RA synthesis with disulfiram , or of RAR receptors with the pan-RAR antagonist Ro-41-5253, or the RARβ antagonist LE135E, greatly reduced the survival of the axotomized neurons.”

“Expectedly, inhibition of RA by disulfiram resulted in downregulation of cEbf2, 3, but did not change cEbf1 expression in somites.”

“ Disulfiram which inhibits the synthesis of retinoid acid may suppress deprivation myopia by up-regulating the expression level of TGF-beta2 mRNA.”

“Furthermore, this enhanced RA catabolism was substantially (approximately 80%) inhibited by nonspecific CYP inhibitors ( disulfiram and liarozole), but was partially (approximately 50%) inhibited by resveratrol (CYP1A1 inhibitor), alpha-naphthoflavone (CYP1A2 inhibitor) and antibodies against CYP1A1 and CYP1A2.”

“These findings are consistent with the conclusion that disulfiram disrupts song maturation by interfering with retinoic acid production.”

“However, when synthesis of retinoic acid was inhibited by disulfiram , or when the function of the retinoid receptors was impaired by using a RAR antagonist, the process of lens regeneration was dramatically affected.”

“4'-(9-Acridinylamino)methansulfon-m-anisidine, an inhibitor of aldehyde oxidase, and disulfiram , a sulfhydryl-group crosslinking agent, were potent inhibitors of retinoic acid synthesis at 10 microM or less, and seemed equipotent in liver and kidney.”