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Last Updated: 2 years ago

Possible Interaction: Disulfiram and NAD

supplement:

NAD

Research Papers that Mention the Interaction

The reaction requires NAD+ as cosubstrate and can be inhibited by disulfiram and citral.
Cell and Tissue Research  •  2000  |  View Paper
The protective effect of the NAD+ against ALDH I and II inactivation by disulfiram and disulphides I, IV, VI-VIII and X is shown.
Ukrainskii biokhimicheskii zhurnal  •  1989  |  View Paper
In the absence of NAD+, the rate of inactivation by disulfiram was biphasic and considerably higher than that in the presence of NAD+.
It is proposed that binding of NAD+ limits access of disulfiram to the thiols at the active site but provides a situation that favours an electrophilic attack of cyanamide and ACP on the thiol groups.
Biochemical pharmacology  •  1983  |  View Paper
Under the former circumstances the activity of the enzyme is little affected, but when the reaction is conducted in the presence of NAD+ the enzyme is activated by approximately 2-fold and is then relatively insensitive to the inactivatory effect of disulfiram.
The Biochemical journal  •  1982  |  View Paper
The complete protection afforded by NAD+ against the action of disulphiram suggests that the essential thiol group may be involved in binding of NAD+ to the xanthine oxidoreductase molecule.
The Biochemical journal  •  1982  |  View Paper
Disulfiram significantly inhibited mitochondrial (45 per cent) and cytosolic (93 per cent) NAD + -dependent aldehyde dehydrogenase, but it did not cause significant inhibition of microsomal NAD + -dependent activity.
Biochemical pharmacology  •  1981  |  View Paper