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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Disulfiram
supplement:
NAD
Research Papers that Mention the Interaction
“The reaction requires NAD+ as cosubstrate and can be inhibited by disulfiram and citral.”
OLN-93 oligodendrocytes synthesize all-trans-retinoic acid in vitro“The protective effect of the NAD+ against ALDH I and II inactivation by disulfiram and disulphides I, IV, VI-VIII and X is shown.”
“In the absence of NAD+, the rate of inactivation by disulfiram was biphasic and considerably higher than that in the presence of NAD+.”
“It is proposed that binding of NAD+ limits access of disulfiram to the thiols at the active site but provides a situation that favours an electrophilic attack of cyanamide and ACP on the thiol groups.”
“Under the former circumstances the activity of the enzyme is little affected, but when the reaction is conducted in the presence of NAD+ the enzyme is activated by approximately 2-fold and is then relatively insensitive to the inactivatory effect of disulfiram.”
“The complete protection afforded by NAD+ against the action of disulphiram suggests that the essential thiol group may be involved in binding of NAD+ to the xanthine oxidoreductase molecule.”
“ Disulfiram significantly inhibited mitochondrial (45 per cent) and cytosolic (93 per cent) NAD + -dependent aldehyde dehydrogenase, but it did not cause significant inhibition of microsomal NAD + -dependent activity.”
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