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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Disulfiram
supplement:
Isoleucine
Research Papers that Mention the Interaction
“Surprisingly, we found that inducing glutathionylation with disulfiram increased the production of O2●-/H2O2 by mitochondria oxidizing glycerol-3-phosphate (G3P), proline (Pro), or α-keto-β-methylvaleric acid (KMV).”
The glutathionylation agent disulfiram augments superoxide/hydrogen peroxide production when liver mitochondria are oxidizing ubiquinone pool-linked and branched chain amino acid substrates.
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