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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Disulfiram
supplement:
Cupric Cation
Research Papers that Mention the Interaction
“However, when mice receiving disulfiram were supplemented with Cu2+ , a significant reduction in tumour growth was observed.”
Prostate cancer: Copper unlocks therapeutic potential of disulfiram“ Disulfiram given to melanoma cells in combination with Cu2+ or Zn2+ decreased expression of cyclin A and reduced proliferation in vitro at lower concentrations than disulfiram alone.”
“ Disulfiram (DSF) has excellent in vitro anticancer activity in the presence of Cu(II).”
“… Cu2+, DS induced cytotoxicity in Raji cells with an IC50 of 0.085 ± 0.015 μM and in Molt4 cells with an IC50 of 0.435 ± … mice was significantly smaller than that in DS or control group, indicating that DS/Cu inhibits the proliferation of Raji cells in vivo.”
“Chemical studies demonstrated a complicated, extracellular redox reaction between Cu(II) and DSF , which forms the complex Cu(deDTC)(2) in high yield, accompanied by oxidative decomposition of small amounts of disulfiram.”
“Moreover, the subsequent administration of disulfiram (DSF) could further chelate with the liberated Cu2+ , yielding toxic bis(N,N-diethyl dithiocarbamato)copper(II) chelates to synergize the therapeutic effect to ablate deep-seated orthotopic gastric tumors.”
Degradable FeCuS-Lipid Nanoparticles Confer Ultrasound-Activated CO Release and O2-Independent Radical Production for Synergistic Therapy.
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