Possible Interaction: Dipyridamole and Inosine

“A downstream metabolite of adenosine, inosine , also potentiated the LPS-induced NO production in a dose-dependent manner while its enhancement effect was also inhibited by dipyridamole.”

“Conversely, from both cocultures and transient cocultures DPR significantly decreased NMDA‐evoked INO but not ADO generation.”

“In neurons, the equilibrative nucleoside transport (ENT) inhibitor dipyridamole (DPR) prevented NMDA‐evoked ADO and INO production, whereas the e‐N inhibitor α,β‐methylene ADP (AOPCP) had no effect.”

“In contrast, dipyridamole significantly increased the ratio of adenosine to inosine.”

“ Dipyridamole , an inhibitor of equilibrative nucleoside transporters, inhibited both adenosine and inosine release from neurons.”

“ Dipyridamol increased significantly inosine levels in the extracellular medium of hippocampal and cortical, but not in cerebellar astrocytes medium.”

“ Dipyridamole (4 µM) inhibited the protective effect of both adenosine and inosine.”

“Transport of inosine , hypoxanthine and adenine was minimally inhibited by 10 microM dipyridamole , however.”

“Incubation of these cells with micromolar concentrations of dipyridamole , a potent inhibitor of nucleoside transport, prevents the excretion of inosine and depresses the rate of purine biosynthesis to that of wild type cells.”

“ Inosine formation was enhanced by dipyridamole.”

“Other nucleosides, dipyridamole and nitrobenzylthioinosine, specifically inhibited the transport of uridine and inosine , and depressed the intracellular accumulation of ribose-1-P and the formation of base commensurate with that inhibition.”