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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Dipyridamole
supplement:
Diallyl Trisulfide
Research Papers that Mention the Interaction
“After adding DATS (10 and 50 μg/mL) in the everted gut sacs, absorption of dipyridamole was remarkably decreased in the ileum and jejunum (p < 0.01).”
“After coadministration and long-term pretreatment of DATS , significantly lower Cmax and AUC0–24 h were observed for intragastric administration of dipyridamole , whereas little change was noted after intravenous dipyridamole administration.”
“…,DATS reduced the … of dipyridamole in rats likely by the modification of the dissolution rate and intestinal absorption of dipyridamole, indicating that combined use of DATS or …-containing supplements with dipyridamole may require caution as low plasma concentrations of dipyridamole may lead to a subtherapeutic effect of this agent.”
Effect of diallyl trisulfide on the pharmacokinetics of dipyridamole in rats
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