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Last Updated: 3 years ago

Possible Interaction: Diphenhydramine and Quinidine

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drug:

Diphenhydramine

supplement:

Quinidine

Research Papers that Mention the Interaction

“On the other hand, lipophilic cationic drugs, such as clonidine, bisoprolol, diphenhydramine , pyrilamine, and imipramine, significantly decreased the uptake of quinidine in MDCK cells.”

Presence of an H+/Quinidine Antiport System in Madin–Darby Canine Kidney Cells

European Journal of Drug Metabolism and Pharmacokinetics • 2015 | View Paper

“The diphenhydramine uptake was significantly inhibited by amantadine and quinidine , but not tetraethylammonium and 1-methyl-4-phenylpyridinium (substrates for well-known organic cation transporters).”

Functional expression of a proton-coupled organic cation (H+/OC) antiporter in human brain capillary endothelial cell line hCMEC/D3, a human blood–brain barrier model

Fluids and Barriers of the CNS • 2012 | View Paper

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